Surface Wrinkled Microsphere Enhanced Irregular Wound Healing Through Synergistic Hygroscopicity, Reversible Wet-Adhesion and Antibacterial Properties

Rapid and effective healing of irregular wounds caused by burns, lacerations, and blast injuries remains a persistent challenge in wound care. Hydrogel microsphere dressings that can adaptively fill and adhere to the wounds without external force are desired to treat irregular wounds, providing an external barrier and accelerating healing. Herein, we created multifunctional cellulose-based surface-wrinkled microspheres with antioxidant, antibacterial, hygroscopicity, wet-adhesion and shape-adaptive capabilities to relieve inflammation, bacteria and excess exudate situations in healing irregular wounds. This dressing rapidly adsorbs exudate and reversibly adheres wetly to the wounds upon being filled, effectively inhibiting bacterial infection and reducing the flooded exudate to accelerate wound healing. Polydopamine (PDA) provides catechol-based tissue bioadhesion to microspheres through π–π stacking or hydrogen bond interaction, and also establishes a bond bridge with an antimicrobial component (thymol), which not only enables the microspheres to stably adhere to the wound to maintain hygroscopicity, but also improves the release of the introduced antimicrobial component (thymol). In vivo assays, as well as histopathological and immunofluorescence studies have shown that multifunctional cellulose-based microspheres have excellent pro-healing abilities and are promising candidates for dehumidification and healing of irregular wound in clinical applications.

在伤口修复领域，由烧伤、撕裂和爆炸导致的不规则创面的快速、有效愈合，仍面临巨大挑战。水凝胶微球敷料符合这类创面愈合的理想治疗需求，其能在无外力作用下自适应填充并贴合不规则创面，形成外部屏障并加速伤口愈合。为此，本文开发了一种具有抗氧化、抗菌、吸湿、湿态黏附和形状自适应性的多功能纤维素基-表面褶皱微球，通过缓解创伤部位的炎症、细菌感染和渗出液过量问题，加速伤口愈合。将微球填充在伤口部位后，微球可快速吸收渗出液并通过可逆的湿态黏附作用贴合伤口表面，有效的抑制细菌感染并减少渗出液累积，加速伤口愈合。聚多巴胺（PDA）的儿茶酚结构通过π-π堆积与氢键作用，赋予微球组织黏附能力，并为抗菌成分（百里酚）提供键合位点，这种结构使微球不仅可以持续的黏附在伤口部位吸收渗出液，还提高了抗菌成分（百里酚）的释放。体内实验、组织病理学和免疫荧光实验的结果表明，该多功能纤维素基微球表现出卓越的促进伤口修复能力，有望在临床应用中成为不规则伤口渗出液吸收和修复的潜在优选材料。

期刊：Small Science

原文链接：https://onlinelibrary.wiley.com/doi/full/10.1002/smsc.202300216